Platforms
Gamecube, PS2
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RE4
In 2004, six years after the events of Resident Evil 2 and 3, the Umbrella Corporation’s secretive activities within Raccoon City have become a public affair. Following an investigation conducted by the Federal government of the United States, several Umbrella officials are implicated and prosecuted. The government formally and indefinitely suspends Umbrella’s business practices, causing the company to become bankrupt.
The game's main protagonist is Leon S. Kennedy, one of the few survivors of the Raccoon City Incident, who was recruited and trained by the U.S. government to become a secret agent after they learned of his actions in Raccoon City. Now a new agent in the Secret Service, Leon is sent on a mission to rescue Ashley Graham, the President’s daughter, who has been kidnapped by a mysterious cult. Leon travels to a Spanish-speaking village in Europe, where he encounters a horde of unruly villagers who pledge their lives to Los Illuminados, the cult that perpetrated Ashley’s kidnapping.

During the course of the mission, Leon is reunited with Ada Wong, a woman Leon met in Resident Evil 2, and Jack Krauser, one of Leon’s former buddies from his years of government training, thought to be dead. He also meets Luis Sera, a former Los Illuminados’ researcher, who aids Leon on his mission before he is killed. By examining Sera’s notes, Leon discovers that Los Illuminados gained control of their subjects by implanting a mind controlling parasite known as Las Plagas into their bodies.
After Osmund Saddler, the leader of the cult, discovers that Leon has rescued Ashley, he commands his subjects to use any means to recover her. Meanwhile, after defeating Bitorez Mendez, Leon and Ashley take refuge inside a castle. A surprise attack by Salazar's minions leads to Ashley’s recapture, forcing Leon to travel to a military and research complex located on a nearby island. After numerous altercations with Saddler's forces, Leon is able to successfully rescue Ashley, and defeat Saddler with Ada's assistance.
Leon recovers a vial containing a Plagas sample from Saddler’s corpse, but Ada forces him to give it to her. She then escapes from the complex in a helicopter, leaving Leon and Ashley to escape via jet-ski.

Resident Evil 4's game mechanics have been completely revamped to incorporate fast-paced gunplay, quick controls and shootouts involving massive crowds of enemies in large open areas. This, combined with an abundance of healing items and ammunition, results in a different gameplay experience from other Resident Evil games. Previous titles in the series have focused on exploration and conservation of ammunition - in RE4, the player can fire more ammunition and kill more enemies in one playthrough than in all of the other Resident Evil games combined (not including the Gun Survivor sub-franchise, in which the player is deliberately given infinite pistol ammunition). A typical play-through can result in the player killing upwards of 900 enemies. Also players have many more in game options to improve the experience.
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