In the first episode, the player takes the role of a troubled writer who has gone to a country retreat to work on his next masterpiece. However, the player soon hears news over the radio of 'strange atmospheric phenomena', and he quickly find himself fighting for survival against hordes of zombies. To make things worse, there are also zombie police officers who are still capable of using weapons and equipment, and prove to be a constant threat (as well as a source of ammunition). In the end, the player is captured by the undead sheriff and imprisoned.

As the zombie officer unlocks your cell door you stand in the belief that there is no escape from your inevitable demise. Perhaps you could ellude the one zombie officer, but there were others waiting, just in case, includeing the zombie sherif. All seemed lost. However at the last moment you hear a voice shouting from outside, and then suddenly an explosion obliders the entire cell wall, allowing you to make your escape. You see a sherif operating a tank turret. He quickly drops down and greets you, warning you that the entire area is flooded with zombies. You and the sherif form an alliance and are on your way...

The final episode opens as the player awaken to find himself in a hospital. A little exploration reveals that this place, too, is full of zombies, and the player's fight continues. The player also finds himself hunted by Marines, apparently called in to attempt to contain the situation. In the end, the player must battle a mad scientist and the zombie sheriff responsible for the mayhem.

They Hunger: Lost Souls is a first-person action commercial game powered by the award-winning Half-Life 2 Source engine from Valve Software. Based upon the highly popular They Hunger mod series, the upcoming title features a completely new horror-survival adventure.

In North-Eastern Europe during the early 1960's, strange anomalies culminate with dead corpses rising from their graves. As a tourist recovering from a tragic accident, you seek shelter in an ancient monastery overrun by bloodthirsty zombies, and become involved in an escalading cascade of calamities.